[레포트(report) ] 병리 4조 우형 논문 EMMPRIN / IntroductionDegradati
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IntroductionDegradation of extracellular...
[레포트(report) ] 병리 4조 우형 논문 EMMPRIN / IntroductionDegradati
IntroductionDegradation of extracellular matrix (ECM) components by matrix metalloproteinases (MMPs) is critical for tumor cell invasion and metastasis [401 and 402]. Since disruption of the basement memane is a crucial step for tumor progression, of MMPs, matrix metalloproteinases-2 (MMP-2) has been noted because of its activity to degrade type IV collagen, a major component of the basement memane, and memane type 1-matrix metalloproteinase (MT1-MMP) has been recognized as a key factor for pro-MMP-2 activation [403]. Recent studies have revealed that tumor cells utilize MMPs such as MMP-2 produced by neighboring stromal cells including fioblasts rather than by tumor cells themselves [404 and 405] for tumor progression, invasion, and metastasis, and that tumor cells can stimulate MMP production by stromal cells via soluble factors such as cytokines [406, 407, 408 and 409] or through cell cell interaction mediated by cell adhesion molecules such as EMMPRIN [410].In additio...
레포트 병리 4조 우형 논문 EMMPRIN / IntroductionDegradati
IntroductionDegradation of extracellular...
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